Pyrene was purified by column chromatography on silica gel using hexane as the eluent. The main fraction was recrystallized from hexane and sublimed
نویسندگان
چکیده
strain A/i mouse following single i.p. administration of B[a]P,4 B[b]F, 5-MeC, CPP, DB[a,hJA, or pyrene. These are all environmen tally prevalent PAH displaying a range of carcinogenic potencies in a variety of test systems (5). The strain A/i mouse model was selected because of its rapid tumor response to a wide variety of chemical carcinogens (6), and because the target tissue for tumorigenesis, the lung, is a relevant target for PAH carcinogenesis in humans.
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